Zoe Christenson-Wick is a Post-Doctoral Research Fellow at Mount Sinai Medical School and will describe the development and use of PhaSER; a low-latency open-source tool which allows her to perform real-time oscillatory phase estimation and apply optogenetic manipulations at precise phases of hippocampal theta during high-density electrophysiological recordings in head-fixed mice while they navigate a virtual environment. Reference:...
In systems neuroscience, datasets are multimodal and include data-streams of various origins: multichannel electrophysiology, 1- or 2-p calcium imaging, behavior, etc. Often, the exact nature of data streams are unique to each lab, if not each project. Analyzing these datasets in an efficient and open way is crucial for collaboration and reproducibility. In this combined webinar and tutorial, Adrien Peyrache and Guillaume Viejo will present Pynapple, a Python-based data analysis pipeline for...
In systems neuroscience, datasets are multimodal and include data-streams of various origins: multichannel electrophysiology, 1- or 2-p calcium imaging, behavior, etc. Often, the exact nature of data streams are unique to each lab, if not each project. Analyzing these datasets in an efficient and open way is crucial for collaboration and reproducibility. In this combined webinar and tutorial, Adrien Peyrache and Guillaume Viejo will present Pynapple, a Python-based data analysis pipeline for...
Nuo Li (Baylor College of Medicine, USA) shares novel insights into coordinated interhemispheric large-scale neural network activity underpinning short-term memory in mice. Relevant techniques covered include: simultaneous multi-regional recordings using multiple 64-channel H probes during head-fixed behaviour in mice. simultaneous optogenetics and population recording. analysis of population recordings to infer interactions between brain regions. Reference: Chen G, Kang B, Lindsey J, Druckmann...
In this webinar, we join Brendan Ito and Teja Bollu who break new-ground in their exciting collaboration exploring real-time motor control using the mouse tongue as a novel model system. With the aid of high-speed videography, tongue movement dynamics can be extracted and related to ongoing activity in the anterolateral motor cortex (ALM) during targeted licking and during perturbations evoked by photoinhibition in the ALM, revealing that ALM activity exhibits performance-related signals...
Join the talented Ali Weber from Tom Daniel's lab and learn how she used our probes in a novel insect preparation to record from sensorimotor neurons controlling the moth wing. Insights on how moths solve the problems of aerodynamic feedback are brought to light leading to an interesting discussion on how this relates to other animal systems in neuroscience.
In this combined webinar and tutorial, with Alessio Buccino and Samuel Garcia, we cover the basics of using SpikeInterface for running multiple spike-sorting packages on extracellular raw spike data, recorded using our advanced silicon neural probes. The talk covers a brief history of spike-sorting, current challenges and describes the benefits and benchmarks of SpikeInterface, as a prelude to a hands-on demo / tutorial session (presented in the next webinar). Spikeinterface is a collection of...
In this combined webinar and tutorial, with Alessio Buccino and Samuel Garcia, we cover the basics of using SpikeInterface for running multiple spike-sorting packages on extracellular raw spike data, recorded using our advanced silicon neural probes. The talk covers a brief history of spike-sorting, current challenges and describes the benefits and benchmarks of SpikeInterface, as a prelude to a hands-on demo / tutorial session (presented in the next webinar). Spikeinterface is a collection of...
In this ground-breaking webinar, Hannah Payne from Dmitry Aronov's lab describes her pioneering work exploring hippocampal place-cells in freely-behaving birds. Learn how she used miniaturised technology to overcome the technical challenges of generating high-channel-count electrophysiology data while working with extremely, behaving small animals. Reference: https://www.science.org/doi/10.1126/science.abg2009
Felicity Gore from Karl Deisseroth's lab describes ChRmine; a novel, red-shifted opsin with high-sensitivity and strong activation dynamics that can drive robust neural responses in deep targets from light delivered from OUTSIDE the skull, thereby removing the need to place often bulky fiber optic cannulas in the brain tissue. Reference: https://www.nature.com/articles/s41587-020-0679-9
Nick Timme (Indiana University - Purdue University Indianapolis) describes how was able to record from thousands of neurons in behaving rats as they they seek and consume alcohol. Nick also describes a novel PCA-based analysis for large-scale neuronal representation analysis. Reference: https://www.nature.com/articles/s41467-022-31731-4
In this webinar we explore the use of probes beyond the central nervous system... Joze Guzman (Institute of Molecular Biology, Austria) presents a unique insight in to the emerging field of human brain organoids and describes how he has optimised this preparation for single unit recording with optogenetic identification. In tandem, Roberto Lopez (University of Michigan) shows how he has used our probes to uncover highly novel single unit functional organisation within the adrenal medulla during...
Hear from leading-lights within the behaving marmoset field: Patrick Jendritza (Ernst Strungman Institute) describes his multi-target chronic probe implants across the visual cortices, encompassing 196-channel recording of single units with optogenetics for > 1 year in each animal. Reza Shadmehr and Paul Hage (Johns Hopkins University) describe their innovative approach for daily acute probe penetration spanning many months in head-fixed behaving marmoset to record cerebellar Purkinje cells;...
Join us for an in-depth presentation by Tahl Holtzman (Founder of Cambridge NeuroTech) covering a general introduction to using our silicon neural probes alongside optogenetic applications in acute and chronic experiments. Surgical approaches for chronic implantation of probes + fibers are also covered. Also hear Huub Terra (Vrije University Amsterdam) describe how he has applied chronically implanted probes with co-aligned fiber cannulas for optogenetic identification of medial prefrontal...
In this double-bill webinar Tahl Holtzman (Founder of Cambridge NeuroTech) offers a general introduction to using our silicon neural probes in a variety of experimental settings encompassing anaesthetised, head-fixed and freely-behaving studies. Surgical approaches for chronic implantation are also covered. Nelson Totah (University of Helsinki) describes how he has applied chronically implanted probes to boost his single unit data yields in head-fixed behaving rats working on a GO / NO-GO task).
