Zoe Christenson-Wick is a Post-Doctoral Research Fellow at Mount Sinai Medical School and will describe the development and use of PhaSER; a low-latency open-source tool which allows her to perform real-time oscillatory phase estimation and apply optogenetic manipulations at precise phases of hippocampal theta during high-density electrophysiological recordings in head-fixed mice while they navigate a virtual environment. Reference:...
Nuo Li (Baylor College of Medicine, USA) shares novel insights into coordinated interhemispheric large-scale neural network activity underpinning short-term memory in mice. Relevant techniques covered include: simultaneous multi-regional recordings using multiple 64-channel H probes during head-fixed behaviour in mice. simultaneous optogenetics and population recording. analysis of population recordings to infer interactions between brain regions. Reference: Chen G, Kang B, Lindsey J, Druckmann...
In this webinar, we join Brendan Ito and Teja Bollu who break new-ground in their exciting collaboration exploring real-time motor control using the mouse tongue as a novel model system. With the aid of high-speed videography, tongue movement dynamics can be extracted and related to ongoing activity in the anterolateral motor cortex (ALM) during targeted licking and during perturbations evoked by photoinhibition in the ALM, revealing that ALM activity exhibits performance-related signals...
Felicity Gore from Karl Deisseroth's lab describes ChRmine; a novel, red-shifted opsin with high-sensitivity and strong activation dynamics that can drive robust neural responses in deep targets from light delivered from OUTSIDE the skull, thereby removing the need to place often bulky fiber optic cannulas in the brain tissue. Reference: https://www.nature.com/articles/s41587-020-0679-9
In this double-bill webinar Tahl Holtzman (Founder of Cambridge NeuroTech) offers a general introduction to using our silicon neural probes in a variety of experimental settings encompassing anaesthetised, head-fixed and freely-behaving studies. Surgical approaches for chronic implantation are also covered. Nelson Totah (University of Helsinki) describes how he has applied chronically implanted probes to boost his single unit data yields in head-fixed behaving rats working on a GO / NO-GO task).
