May 26, 2021

Deep-brain optogenetics without intracranial surgery

Felicity Gore from Karl Deisseroth's lab describes ChRmine; a novel, red-shifted opsin with high-sensitivity and strong activation dynamics that can drive robust neural responses in deep targets from light delivered from OUTSIDE the skull, thereby removing the need to place often bulky fiber optic cannulas in the brain tissue.

Reference:

https://www.nature.com/articles/s41587-020-0679-9

optogenetics, mice, freely-behaving, optotagging, opsins, amygdala, VTA

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Deep-brain optogenetics without intracranial surgery

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