In this webinar we explore the use of probes beyond the central nervous system... Joze Guzman...
Deep-brain optogenetics without intracranial surgery
Felicity Gore from Karl Deisseroth's lab describes ChRmine; a novel, red-shifted opsin with high-sensitivity and strong activation dynamics that can drive robust neural responses in deep targets from light delivered from OUTSIDE the skull, thereby removing the need to place often bulky fiber optic cannulas in the brain tissue.
Reference:
https://www.nature.com/articles/s41587-020-0679-9