---
title: Manipulating single-unit theta phase-locking with PhaSER: An open-source tool for real-time phase estimation and manipulation
description: real-time oscillations during epilepsy, hippocampus, mice, electrophysiology silicon neural probes optogenetics
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 May 9, 2023

# Manipulating single-unit theta phase-locking with PhaSER: An open-source tool for real-time phase estimation and manipulation

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Zoe Christenson-Wick is a Post-Doctoral Research Fellow at Mount Sinai Medical School and will describe the development and use of *PhaSER*; a low-latency open-source tool which allows her to perform real-time oscillatory phase estimation and apply optogenetic manipulations at precise phases of hippocampal theta during high-density electrophysiological recordings in head-fixed mice while they navigate a virtual environment.

Reference:

[https://www.biorxiv.org/content/10.1101/2023.02.21.529420v1.full](https://www.biorxiv.org/content/10.1101/2023.02.21.529420v1.full?utm_campaign=Webinars&utm_source=hs_email&utm_medium=email&_hsenc=p2ANqtz-85KPGxNc0Vy0YqCXfYByELlQJRvPb5xTG56MrGyzB_4bq2Y__TGkqyN18CWUjFGlKUWZA2)

GitHub resources:

[https://github.com/ShumanLab/PhaSER](https://github.com/ShumanLab/PhaSER)

 

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