The marriage of theory and approach: Laminar silicon probes and the measure of corticohippocampal throughput in Pten knockout mice

This webinar will showcase how we can integrate abstract conceptual physiological frameworks with practical, actionable methods to understand, analyze, or resolve complex questions in basic and translational neuroscience. We’ll do this in 4 steps:

• • 1) Provide background into theory and the basic physiological mechanisms of corticohippocampal circuitry apk,nd the generation of theta oscillations;
  • 2) Describe the longstanding need for tools that address how alterations to cellular morphology in early development affect corticohippocampal dynamics underlying learning and memory;
  • 3) Demonstrate how high-density laminar silicon neural probes, used in combination with genetic models for neurodevelopmental disorders localized to the dentate gyrus(Pten knockout), offer novel insights into mechanisms of corticogranule synaptic input and granular somatic output; and
  • 4) Show preliminary data for how Pten cellular features scaled to network levels can be predictive of cognitive deficits in complex spatial navigation tasks.

Jeremy Barry

Epilepsy Cognition and Development Lab, Larner College of Medicine at the University of Vermont, USA

Jeremy Barry is an Associate Professor of Neurological Sciences at the Larner College of Medicine at the University of Vermont where he runs the Epilepsy Cognition and Development Laboratory. He is a recent winner of the Lucey prize for Innovative research for infant or child health and the Dean’s Excellence in Research award. His current work straddles basic and translational neuroscience in the study of convergent mechanisms of circuit discoordination in genetic and acquired developmental encephalopathy models. In the few moments he’s not complaining about how complicated the dentate gyrus is, he enjoys birding and taking long walks in the Vermont countryside.

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